Expertise

• Analysis of drug concentrations
  

  • Gas chromatography
  • HPLC
  • EMIT
  • LC/MS/MS
  • Radioimmunoassay
  • Drugs of abuse

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• Bridging studies
  

  You can download information about Bridging studies from brochures section.

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• Cardiovascular
  

  

  • Central ECG monitoring (SpaceLabs) on all beds
  • Telemetry (SpaceLabs) throughout premises
  • 12-lead ECG with electronic transfer capability
  • High-speed high-gain surface ECG
  • 24-h ambulatory 12-lead ECG and blood pressure monitoring
  • Exercise ECG
  • Passive tilt testing
  • Systolic time intervals
  • Impedance cardiography
  • Doppler aortic velography
  • Laser Doppler flowmetry
  • Forearm blood flow
  • Hand venous reflex measurement
  • Fingertip photo-plethysmography
  • Catecholamine and prostanoid agonist/antagonist trials
  • Thorough QT

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• Central nervous system
  

   

  • Psychomotor tests
  • Coordination tests
  • Cognitive function assessment
  • Scopolamine model of dementia
  • Analgesic assessment
  • Body sway
  • Saliva flow rate
  • 5-HT1A receptor mediated function tests
  • EEG
  • Positron emission tomography (in collaboration with Hammersmith Imanet)

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• Dermatological
  

  

  • Transdermal bioavailability
  • Cutaneous irritancy and sensitisation
  • Extracellular fluid and skin drug pharmacokinetics
  • Penile sensitivity
  • Histamine, 5-HT or substance P intradermal tests
  • UV erythema challenge tests
  • Allergen tests

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• Drug-drug interactions
  

  

  • Digoxin, theophylline, warfarin
  • Oral contraceptives
  • Anticonvulsants
  • CYP3A4 inhibitors

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• Gastrointestinal
  

  

  • Intra-gastric and oesophageal ambulatory pH monitoring (24-h)
  • Pentagastrin- or histamine-stimulated acid secretion
  • Gastro-intestinal transit time
  • Intra-gastric drug infusion
  • Intra-jejunal drug administration
  • Faecal red blood cell loss (using ⁵¹Cr-labelled red cells)
  • Upper gastro-intestinal endoscopy
  • Ambulatory gastric emptying using caesium iodide detector, ^99mTc radiolabelled meal and gamma camera
  • Gastric emptying using paracetamol kinetics
  • Gall bladder scintigraphy using ^99mTc radiolabelled HIDA (in collaboration with Radiological Sciences Unit, Hammersmith Hospital)

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• Haematological
  

  

  • Bleeding time
  • Platelet aggregometry
  • FACS analysis
  • Red blood cell deformability
  • Coagulation trials
  • Cytokine assay
  • Assay of red and white blood cell precursors

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• Microdosing
  

  For microdose studies, we work with Xceleron UK, who provide the accelerator mass spectrometry service:  http://www.xceleron.com

  You can download information about microdosing from our brochures section.

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• Ocular
  

  • Non-contact tonometry
  • Goldmann applanation tonometry
  • Slit lamp examination
  • Photographic or twin-hole static pupillometry
  • Infrared static and dynamic pupillometry

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• Positron Emission Tomography (PET)
  

  You can download information about PET from our brochures section.

  Working with Hammersmith Imanet PET unit, a branch of GE Healthcare: http://www.imanet.com/

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• QT
  

  You can download information about QT from brochures section.

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• Radiolabelled
  

  • Licence for radiolabelled trials
  • Radiation Protection Supervisor
  • ADME trials
  • Microdosing trials

  Find out more about studies of radiolabelled products.

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• Renal
  

  

  • ⁵¹Cr - EDTA method for glomerular filtration rate
  • ¹²⁵I - Hippuran method for effective renal plasma flow
  • Urinary transferrin, microalbumin and alpha-1-microglobulin to assess potential nephrotoxicity
  • Urinary enzyme assay - NAG
  • Renin and angiotensin assessments

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• Respiratory
  

  

  • Peak expiratory flow rate
  • Standard spirometry - Vitalograph Gold Standard
  • Computer-assisted spirometry
  • Nasal cannula Lung volumes by helium dilution
  • CO transfer factor
  • Minute volume
  • Pulse oximetry on all beds
  • End tidal pCO2
  • Transcutaneous pO2
  • Bronchoscopy and broncho-alveolar lavage
  • Histamine, methacholine and AMP challenge
  • Allergen challenge
  • Nitric oxide
  • Sputum analysis
  • Acoustic rhinometry

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