Expertise

  • Analysis of drug concentrations
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    • Preparing urine samplesGas chromatography
    • HPLC
    • EMIT
    • LC/MS/MS
    • Radioimmunoassay
    • Drugs of abuse
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  • Bridging studies
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    Bridging studiesYou can download information about Bridging studies from brochures section.

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  • Cardiovascular
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    Hammersmith Medicines Research

    • Central ECG monitoring (SpaceLabs) on all beds
    • Telemetry (SpaceLabs) throughout premises
    • 12-lead ECG with electronic transfer capability
    • High-speed high-gain surface ECG
    • 24-h ambulatory 12-lead ECG and blood pressure monitoring
    • Exercise ECG
    • Passive tilt testing
    • Systolic time intervals
    • Impedance cardiography
    • Doppler aortic velography
    • Laser Doppler flowmetry
    • Forearm blood flow
    • Hand venous reflex measurement
    • Fingertip photo-plethysmography
    • Catecholamine and prostanoid agonist/antagonist trials
    • Thorough QT
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  • Central nervous system
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    • Psychomotor tests
    • Coordination tests
    • Cognitive function assessment
    • Scopolamine model of dementia
    • Analgesic assessment
    • Body sway
    • Saliva flow rate
    • 5-HT1A receptor mediated function tests
    • EEG
    • Positron emission tomography (in collaboration with Hammersmith Imanet)
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  • Dermatological
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    Hammersmith Medicines Research

    • Transdermal bioavailability
    • Cutaneous irritancy and sensitisation
    • Extracellular fluid and skin drug pharmacokinetics
    • Penile sensitivity
    • Histamine, 5-HT or substance P intradermal tests
    • UV erythema challenge tests
    • Allergen tests
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  • Drug-drug interactions
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    Hammersmith Medicines Research

    • Digoxin, theophylline, warfarin
    • Oral contraceptives
    • Anticonvulsants
    • CYP3A4 inhibitors
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  • Gastrointestinal
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    Hammersmith Medicines Research

    • Intra-gastric and oesophageal ambulatory pH monitoring (24-h)
    • Pentagastrin- or histamine-stimulated acid secretion
    • Gastro-intestinal transit time
    • Intra-gastric drug infusion
    • Intra-jejunal drug administration
    • Faecal red blood cell loss (using 51Cr-labelled red cells)
    • Upper gastro-intestinal endoscopy
    • Ambulatory gastric emptying using caesium iodide detector, 99mTc radiolabelled meal and gamma camera
    • Gastric emptying using paracetamol kinetics
    • Gall bladder scintigraphy using 99mTc radiolabelled HIDA (in collaboration with Radiological Sciences Unit, Hammersmith Hospital)
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  • Haematological
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    Hammersmith Medicines Research

    • Bleeding time
    • Platelet aggregometry
    • FACS analysis
    • Red blood cell deformability
    • Coagulation trials
    • Cytokine assay
    • Assay of red and white blood cell precursors
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  • Microdosing
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    For microdose studies, we work with Xceleron UK, who provide the accelerator mass spectrometry service:  http://www.xceleron.com

    You can download information about microdosing from our brochures section.

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  • Ocular
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    • Non-contact tonometry
    • Goldmann applanation tonometry
    • Slit lamp examination
    • Photographic or twin-hole static pupillometry
    • Infrared static and dynamic pupillometry
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  • Positron Emission Tomography (PET)
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    PETYou can download information about PET from our brochures section.

    Working with Hammersmith Imanet PET unit, a branch of GE Healthcare: http://www.imanet.com/

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  • QT
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    You can download information about QT from brochures section.

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  • Radiolabelled
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    • Scintillation countingLicence for radiolabelled trials
    • Radiation Protection Supervisor
    • ADME trials
    • Microdosing trials

    Find out more about studies of radiolabelled products.

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  • Renal
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    Hammersmith Medicines Research

    • 51Cr - EDTA method for glomerular filtration rate
    • 125I - Hippuran method for effective renal plasma flow
    • Urinary transferrin, microalbumin and alpha-1-microglobulin to assess potential nephrotoxicity
    • Urinary enzyme assay - NAG
    • Renin and angiotensin assessments
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  • Respiratory
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    Hammersmith Medicines Research

    • Peak expiratory flow rate
    • Standard spirometry - Vitalograph Gold Standard
    • Computer-assisted spirometry
    • Nasal cannula Lung volumes by helium dilution
    • CO transfer factor
    • Minute volume
    • Pulse oximetry on all beds
    • End tidal pCO2
    • Transcutaneous pO2
    • Bronchoscopy and broncho-alveolar lavage
    • Histamine, methacholine and AMP challenge
    • Allergen challenge
    • Nitric oxide
    • Sputum analysis
    • Acoustic rhinometry
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