Respiratory pharmacology is probably the area in which HMR has the greatest expertise and experience, not least because several of our medical staff have a longstanding interest in asthma and allergy.  As you’d expect, we’re well equipped to do a wide range of spirometry measurements, including

  • peak expiratory flow rate
  • FEV & FVC
  • airways resistance (sGaw) by whole-body plethysmography

We can also monitor

  • oxygen saturation
  • transcutaneous pO2
  • end-tidal pCO2
  • exhaled NO

At the most sophisticated level, we can measure

  • CO transfer factor
  • lung volumes by helium dilution.

Inhalation challenge

Our repertoire of pharmacodynamic tests includes inhalation challenge with

  • allergens
  • histamine
  • methacholine
  • AMP

with close monitoring and ‘rescue’ medication as necessary.

Sputum sampling

The HMR Laboratory offers on-site analysis of sputum – most often, for eosinophil and neutrophil counts.

Bronchoscopy and Bronchoalveolar lavage

HMR is truly exceptional in having an on-site endoscopy suite, which allows us to incorporate bronchoscopy and bronchoalveolar lavage in our trials of respiratory medicines in healthy volunteers and patients.



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